Yeah, that's a good question. Would a cluster of computers operating in a distributed manner infringe a claim to a single "computer system"?
Of course, a method claim would cover that.
At one time, I had some boilerplate in the Spec that a computer system included multiple individual computers operating in a coordinated fashion to exhibit the behavior described therein. I'll have to give that some more thought as to how thoroughly I carry that through the Spec and through the claims.
I wonder to what degree I can claim computer readable media in which the logic is distributed across multiple media. For example, what if an otherwise infringing product is distributed in multiple parts -- e.g., one on CD and the other by download?
As for the reverse, whether a single device can be a "system", I think it's pretty clear that it can. You can buy an SoC (system on a chip). If a "system" can be realized in a single chip, it seems clear that a "system" can be a whole device.
As Karen noted, DoE should cover logic that is merely converted from a single computer to a distributed implementation, something that, in and of itself, is not new. However, there is some language in case law that requires that the equivalent implementation was not known during prosecution of the claims -- the typical example being replacement of vacuum tubes with transistors, the presumption being that the invention of transistors happened when the claims could no longer be readily amended. I don't remember whether that particular part of Festo survived the SCt. I believe it's at least a factor, but probably not controlling.
As I've commented numerous times, the law more or less requires patent applicants to be clairvoyant, perhaps omniscient. It doesn't hurt to be a minor deity.
Regards.