Why do you consider the argument worthwhile? I'm sure there are other likely losing arguments that the ACLU did not bother with. After all, we're currently second guessing the side that won at the district court level.
Because I think that, if the judges are going to consistently apply the law, then they likely should invalidate the Myriad claims on printed-matter doctrine grounds.
In other words, I'm not persuaded by the counter-arguments:
1. DNA is not printed matter - it doesn't have to be printed matter, the doctrine doesn't depend on a particular medium
2. If you apply this to DNA, then you have to invalidate all chemical claims - DNA is not like all chemical compounds, DNA is an information-transmitting and message-encoding compound unlike virtually any other compound known in the universe
3. If you apply this to DNA, then you have to apply it to Beauregard and software claims - the status of software claims is totally in the air because the Supreme Court hasn't meaningfully addressed them in decades, and the few cases that do address them provide almost no meaningful guidance
4. your argument is just weak - this is just a generic gut-feeling argument that is not persuasive and is almost impossible to respond to
The best counter-argument, I think, is that the printed matter doctrine doesn't apply if there is a recited functional inter-relationship between the expression and the other claim elements - and here the claims recite that the expression codes for a protein. Still, I think the argument is interesting and worth discussing (maybe I overstate its relevance). Also, I don't that the Supreme Court has ever addressed or countenanced this "functional inter-relationship" prong of the CAFC's printed matter test.
I can imagine a lot of expressions having a structural interrelationship with machinery, without thinking that this should be a point of patentability: suppose I change the password on my computer to "zxczxcasdawefd." Then I write a claim to a computer "wherein the computer is password protected so that the computer only allows access to users upon the entering of the password 'zxczxcasdawefd.'" Suppose that "zxczxcasdawefd" (or the expression of your choice) is not known in the prior art. Am I entitled to a patent now? That seems to violate the spirit, if not the letter, of the printed matter doctrine.
I understand that the ACLU is an expert in First Amendment issues and not patent issues. But if they, and the many other plaintiffs, are going to give the whole array of arguments against Myriad, including unprecedented arguments like the First Amendment one, I would have expected them to cite the printed matter doctrine, if they even considered it.