I've spent a lot of time thinking about setting my own shop up recently as well. Primarily because New Hampshire is not exactly a hot bed of IP, and secondarily because I want to move even further north (where the opportunities get even slimmer).
I haven't read the book MYK mentioned, but I'm sure they are a good place to start. As for online resources, check out
www.myshingle.com. I have found that there is some solid practical advice on that site, as well as a lot of resources for the solo or would be solo practitioner.
Another option for breaking into the "solo" practice arena would be to first associate with one or two attorneys with similar or complementary practices. It doesn't have to be a formal partnership. Just an arrangement whereby you can learn the challenges of small firm practice, while still having someone real to turn to for advice.
Because I am a bit of a wuss, I personally am leaning towards associating with a very small firm first, before opening my own shop. If you are more of a "jump in with both feet" kind of guy/gal, then by all means go for it!
Best,
Klav