I'm no expert in antitrust and patents, but I beleive that the
Nobelpharma AB v. Implant Innovations, Inc. 141 F.3d 1059 (Fed. Cir. 1998) (available at
http://www.ll.georgetown.edu/Federal/judicial/fed/opinions/96opinions/96-1463.html) contains the answers you seek.
In general, the Nobelpharma case says that a patentee who brings an infringement suit can be stripped of its immunity from the antitrust statues if "the alleged infringer (the antitrust plaintiff) proves (1) that the asserted patent was obtained through known and willful fraud within the meaning of
Walker Process Equipment, Inc. v. Food Machinery and Chem. Corp., 382 U.S. 172, 177 (1965); or (2) that the infringement suit was "a mere sham to cover what is actually othing more than an attempt to interfere directly with the business relationships of a competitor,"
Eastern R.R. Presidents Conference v. Noerr Motor Frieght, Inc., 365 U.S. 127, 144 (1961)."
Regarding (1): the antitrust plaintiff must first prove that the patentee "obtained the patent by knowingly and willfully misrepresenting facts to the [PTO]," i.e., fraud. 382 U.S. at 177. The elements of Walker Process fraud are set forth in
Norton v. Curtiss, 433 F.2d 779, 792-94 & n. 12 (CCPA 1970).
Regarding (2): to prove a "sham" suit, the antitrust plaintiff must prove that the suit was (A) objectively baseless (no reasonable litigant could expect to win) and (B) motivated by a desire to impose anti-competitive injury, as opposed to obtaining a justifiable legal remedy.
Note that proving fraud and/or a sham litigation only removes the patentee's immnuity from the antitrust statutes. A substantive antitrust claim must still be proven.
In your case, it would seem that option (1) under the Nobelpharma case would not be available, because the patentee did not know of the prior art during prosecution of the underlying application. It also seems that a case under option (2) would be shakey, because you stated that the prior art potentially only "weakens" the patent. Your best option would be to obtain a qualified opinion of counsel that finds the claims of the patent invalid as anticipated or obvious. Once you have that in hand, you could negotiate with the patentee for a reduced or no royalty license.
As for the duty of disclosure, it is well settled that the duty to bring material information to the attention of the PTO ends once the patent issues. There is also no requirement for a patentee to request reissue or reexamination of any patent they own.